Study shows EPO significantly reduces menopausal hot flashes

April 2013


To determine if Evening Primrose Oil (EPO) significantly reduces hot flashes and improves associated quality of life factors in menopausal women.

Study 1 Design:

  • Randomized, double-blind, placebocontrolled clinical trial
  • 56 menopausal women aged 45-59 years with self-reported history of hot flashes (more than 4 times daily) and no previous treatment for it
  • Took two 500 mg capsules of EPO daily or an equivalent number of placebo capsules for 6 weeks
  • Assessments were completed before and after treatment

NOTE: Hot flashes are a common experience for menopausal women, and for many, are severe enough to significantly compromise their overall sense of well-being and quality of life.

Study Assessments:

1. Hot Flash Daily Reference Scale (HFDRS) - determines impact on specific activities of daily living including:

  • Work (at home and outside)
  • Social activities
  • Mood
  • Concentration
  • Enjoyment of life
  • Relations with others
  • Leisure activities
  • Sleep
  • Sexuality
  • Total quality of life

2. Descriptive characteristics of their hot flashes:

  • Frequency (over a 24 hour period)
  • Severity on a scales of 0 (not at all) to 10 (extremely)
  • Duration in minutes


EPO decreases the intensity of hot flash attacks including frequency, severity and duration and significantly improves social activities, relations with others and sexuality.

For more Information:
Wassen International Ltd
We Work Paddington
2 Eastbourne Terrace
W2 6LG

Tel: 0203 8651739


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